Neuromodulation has been long thought to be important for regulating brain states, perception and decision making. Disregulation of neuromodulatory systems has been identified in several psychiatric diseases. Based on decades of work mainly in brain slices and anesthetized animals, we have accumulated a lot of knowledge of the molecular and cellular mechanisms of these neuromodulators. However, what is currently lacking is how these transmitters regulate perception and behavior. We now have the tools and methods to study these important questions.
Well-controlled perceptual behavior
In vivo electrophysiology: intracellular whole-cell patch clamp, extracellular spike recording
In vivo calcium imaging
Molecular and genetic tools to target specific cell types
Computational modeling and theoretic approaches for network